pharmacogenetics

FIND OUT INFORMATION ABOUT HOW YOUR DNA MIGHT AFFECT YOUR RESPONSE TO CERTAIN MEDICATIONS.

A DNA test for medication? That's what we call pharmacogenetics! With GenetiConcept™, you and your physician may get a better idea of how you might respond to certain drugs.

  • Take a glimpse into your medication response through a simple pharmacogenetics testing.
    Pharmacogenetics is the study of how genes affect a person's response to drugs. This new field allows us to combine genomics and pharmacology to develop safe and effective medication dosages which are specific to an individual's DNA makeup.
  • Engage in your health care.
    The way your body reacts to a drug can be affected by your body size, food, age, use of other drugs, DNA and presence of other conditions. Sharing your medication results report with your doctor can provide him with useful information about how you may respond to a certain medication.

See our list of medications we test for and few examples

pharmacogenetics

Example 1 : Thiopurine drugs

What are they used for ?

The thiopurine-based drugs are purine anti-metabolites generally prescribed for acute-lymphoblastic leukemia condition, autoimmune disorders (such as Rheumatoid Arthritis, Crohn's disease) and organ transplant recipients.

TPMT gene

TPMT is an enzyme that deactivates thiopurine-based drugs. TPMT genetic variants result in decreased TPMT activity. This results to a slow inactivation of thiopurine, thus, leading to an accumulation of thiopurine in the body and in undesired side effects.

Example 2 : Caffeine metabolism

Many individuals get jumpy just after having some caffeine (such as drinking coffee), while others can swallow a Venti-Americano without feeling any effects. One part of this variation is the result of to the development of tolerance that takes place by drinking coffee regularly; but there are also genetic variability in how individuals metabolize caffeine.

Pharmacogenetics and coffee

Caffeine is mainly metabolized by a liver enzyme called CYP1A2 (cytochrome enzyme). Various research studies demonstrated that a genetic variation (rs762551) determines how fast CYP1A2 metabolizes caffeine. Individuals with the CYP1A2 slow version who drank between 2-3 cups of coffee per 24hours had a widely higher odds of a non fatal type heart-attack. The study also demonstrated that individuals who had the CYP1A2 fast version, in contrast, may have actually decreased their odds of heart attack by drinking coffee.


We are the world-leading pharmacogenetics company. Take a look at the list of medications we test for

Neuropsychiatric – Pain Management

duloxetine (Cymbalta)
tiagabine (Gabitril)

Antipsychotic

aripiprazole (Abilify)
asenapine (Saphris)
chlorpromazine (Thorazine)
clozapine (Clozaril)
haloperidol (Haldol)
Iloperidine (Fanapt)
lurasidone (Latuda)
olanzapine (Zyprexa)
perphenazine (Trilafon)
promazine (Sparine)
quetiapine (Seroquel)
risperidone (Risperdal)
thioridazine (Mellaril)
ziprasidone (Geodon)

Other

caffeine
sildinafil (Viagra)
theophylline

Cardiovascular – Antiarrhythmic

amiodarone (Cordarone)
dofetilide (Tikosyn)
flecainide (Tambocor)
propafenone (Rythmol)
quinidine (Various brands)

Immunological

cyclosporine (Gengraf)
hydrocortisone tacrolimus (Prograf)
zafirlukast (Accolate)

Neuropsychiatric – Antidepressant

amitriptyline (Elavil)
buproprion
doxepin (Sinequan, Silenor, Prudoxin, Zonalon)
citalopram (Celexa)
desvenlafaxine (Pristiq)
clomipramine (Anafranil)
desipramine (Norpramin)
escitalopram (Lexapro)
fluoxetine (Prozac)
imipramine (Tofranil)
mirtazapine (Remeron)
nefazodone (Serzone)
vilazodone (Viibryd)
nortriptyline (Aventyl,Pamelor)
venlafaxine (Effexor)
paroxetine (Paxil)
trazodone (Oleptro)
sertraline (Zoloft)

Neuropsychiatric – Anxiolytic

alprazolam (Xanax)
buspirone (BuSpar)
diazepam (Valium)
midazolam (Versed)
phenobarbital triazolam (Halcion)
zolpidem (Ambien)

Steroids

estradiol
progesterone
testosterone

Pain Management

alfentanil (Alfenta)
carisoprodol++ (Soma)
celecoxib (Celebrex)
codeine++
cyclobenzaprine (Flexaril)
fentanyl (Actiq, Duragesic, Sublimaze)
hydrocodone++
ibuprofen (Advil, Motrin)
lidocaine (xylocaine, various brands)
meperidine (Demerol)
naproxen (Aleve)
oxycodone++ (Oxycontin)
ropivacaine (Naropin)
tapentadol (Nucynta)
tizanidine (Zanaflex)
tramadol++ (Ultram)
zolmitriptan (Zomig)

Neuropsychiatric – Pro-cognitive Drug

tacrine (Cognex)

Cardiovascular – Cholesterol Lowering

atorvastatin (Lipitor, Caduet)
fluvastatin (Lescol)
lovastatin (Mevacor)
pravastatin (Pravachol)
rosuvastatin (Crestor)
simvastatin (Zocor)

Cardiovascular – Antihypertensive

amlodipine (Norvasc)
carvedilol (Coreg)
diltiazem (Cardizem)
felodipine (Plendil)
lercanidipine (Zanidip)
losartan ++(Cozaar)
metoprolol (Lopressor, Toprol)
nebivolol (Bystolic)
nifedipine (Adalat, Procardia)
nisoldipine (Sular)
nitrendipine
propanolol (Inderal)
timolol (Blocadren)

Anti-Infectives

clarithromycin (Biaxin)
efavirenza (Sustiva)
erythromycin (E-Mycin)
indinavir (Crixivan)
nelfinavir (Viracept)
ritonavir (Norvir)
saquinavir (Invirase)
telithromycin (Ketek)

Cardiovascular – Anticoagulant

clopidogrel ++ (Plavix)
rivaroxaban (Xarelto)
ticargelor (Brilinta)
warfarin (Coumadin)

Oncology


cyclophosphamide (Cytoxan)++
docetaxel (Taxotere)
ifosfamide tamoxifen ++ (Nolvadex)
vincristine (Vincasar, Oncovin)


What would you do if you knew there was a simple and affordable pharmacogenetics test that could protect you from the 4th leading cause of death ?


Knowledge is power. Get your DNA test for medication and much more!

All information you need for an amazing health and wellness

All-in one DNA Test available! Only $279 including all taxes